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Welcome to Boston!
Boston is a great place to live and work. From the
Boston Symphony Orchestra to the Museum of Fine Arts,
from Newbury Street galleries to the bookstores of Harvard
Square, this cosmopolitan city has enough cultural attractions
to keep you busy for a lifetime. 
Boston is America’s 20th largest city with a population of 650,000 and it has the nation's highest concentration of colleges with more than 250,000 students flocking to the city each fall. Boston is a city steeped in history where you can walk to Paul Revere's House, the Old North Church, the Boston Tea Party and Massacre sites, Faneuil Hall, the U.S.S. Constitution, the country’s first public library and ride the country’s first subway system to Fenway Park – home to the 2004 World Series Champions – the Boston Red Sox. Boston is also a city looking ahead to tomorrow. For centuries Boston has stood at the forefront of technological and civic transformation attracting scholars from across the world.
 The Center for Human Genetic Research is located in the new Simches Research Center at the Massachusetts General Hospital. Situated in the center of the city and along the beautiful Charles River, the Massachusetts General Hospital is the third oldest hospital in the United States and the largest in New England. It consistently ranks as one of the country's best hospitals by U.S. News and World Report.
The CHGR offers an exceptional opportunity to learn and grow in an exciting and stimulating environment. If you'd like to join our team, have a look at our job opportunities below!
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Please contact individual
faculty directly to inquire about postdoctoral training
opportunities. While all faculty are always interested
in hearing from prospective applicants, below are some
specifically advertised positions.
Postdoctoral Fellow (Chemical Genomics)
Job Description: The Massachusetts General Hospital
Center for Human Genetic Research/Harvard Medical School
is seeking a highly motivated post-doctoral fellow in
the area of chemical genomics and stem cell models of
human disease. This is a unique opportunity for working
in a fast-paced, and highly collaborative research group
working at the interface of chemistry, biology, and
medicine. The emphasis of the position will be on the
use of reprogramming methods to generate genetically
accurate models of human diseases mechanisms and the
implementation of cell-based assays using high-content
imaging and automated microscopy. Candidates will be
required to use molecular and cell biology techniques,
including maintaining and manipulate mammalian fibroblast
and stem cell lines and using viral-mediated gene delivery.
The position will also require familiarity with the
use of genomic analysis methods, including gene expression
profiling and SNP detection.
Qualifications: PhD in cell biology, neurobiology,
or stem cell biology or related field. Must posses familiarity
with the operation of standard lab equipment, and techniques
related to mammalian cell culture, fluorescence microscopy,
immunocytochemistry, and molecular biology. Must have
excellent computer skills and ability to perform basic
quantitative analysis of large data sets. More advanced
statistics or programming skills a plus. Requires effective
oral and written communication skills along with meticulous
laboratory technique and recording skills. Must be able
to use discretion to organize workflow and to change
methodologies to optimize work results and communicate
effectively with all levels of staff to ensure that
work supports team goals.
Interested applicants should send curriculum vitae and
names of three references to:
Dr. Stephen Haggarty, Center for Human Genetic Research,
Massachusetts General Hospital, 185 Cambridge Street,
Boston, MA 02114, e-mail: haggarty@chgr.mgh.harvard.edu
Post-Doctoral Fellow
(Psychiatric Genetics, Pharmacogenetics, and Statistical
Genetics)
The Psychiatric and Neurodevelopmental Genetics Unit
in the MGH Center for Human Genetic Research and the
Psychiatric Genetics Program in Mood and Anxiety Disorders
in the MGH Department of Psychiatry has an immediate
opening for a postdoctoral position to conduct cutting-edge
genetic, statistical and bioinformatic analyses of large-scale
studies of a range of psychiatric phenotypes including
disease susceptibility and pharmacogenetic outcomes.
Ongoing studies include genomewide and candidate gene
analyses of antidepressant response, psychotic, mood,
and anxiety disorders, and substance use disorders.
Close supervision and intensive training will be provided
by a team of collegial experts in neuropsychiatric genetics,
statistical genetics, bioinformatics, and genetic epidemiology.
We seek a highly motivated and dedicated MD or PhD in
genetics, bioinformatics or statistical genetics with
excellent quantitative skills, proven ability to work
well in a collaborative environment, fluency with all
modes of communication in English, and strong writing
skills. The successful applicant will have strong training
in statistics or biostatistics, data mining, and genetic
analysis as well as experience with database management
and computer programming. To apply, please send a single
email containing your CV, a short statement describing
your qualifications for this position, and contact information
for three professional references to:
Dr. Jordan W. Smoller
e-mail: jsmoller@hms.harvard.edu
Postdoctoral Research Fellow
A position for a postdoctoral research fellow is available
in the Center for Human Genetic Research at Massachusetts
General Hospital/Harvard Medical School for a highly
motivated individual interested in studying the mechanisms
underlying CAG trinucleotide repeat instability in Huntington’s
disease (HD). The position is available initially for
two years and offers the opportunity to work in a highly
stimulating and collaborative research environment.
The mutant HD CAG repeat is unstable and prone to somatic
expansion in a tissue-specific manner. Chromatin structure
and DNA methylation are strongly implicated as factors
that can modify CAG repeat instability. With the aim
of understanding the basis for the tissue-specific somatic
expansion, the project will focus on investigating whether
there are tissue-specific differences in the proteins
that bind to the expanded HD CAG repeat, in chromatin
organization and in DNA methylation of the repeat region.
The project forms part of a research program directed
at using genetic approaches to dissect the mechanisms
involved in germline and somatic repeat instability
and pathogenesis in HD. Candidates should hold a Ph.D.
in Molecular Biology, Biochemistry or related field,
have a strong background in molecular biology techniques,
preferably with experience in protein biochemistry.
Specific expertise in chromatin immunoprecipitation
(ChIP), chromatin biochemistry or DNA methylation is
a plus. Please email CV and contact information for
three professional references to:
Dr. Vanessa Wheeler
email: w heeler@helix.mgh.harvard.edu
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Research Laboratory Technician
Overall Responsibility:
As part of a dynamic neuropsychiatric genetics group
that is actively searching for the genetic causes of
schizophrenia and bipolar disorder, oversees projects
that are designed to manage the team’s technical
processes. Oversees all aspects of bench level experiments
in the lab including, but not limited to, PCR based
genotyping, RNA preparation, Gel Electrophoresis and
Quantification of DNA. Techniques include DNA sequencing,
and SNP genotyping via Sequenom MassArray. Experience
with tissue culture and molecular biology techniques
a plus. Assists project lead in development of protocols
for experiments, conducting experiments to determine
approaches for meeting project goals, and evaluating
feasibility of new projects. Analyzes quality and quantity
of experimental data, identifies technical problems,
revises protocol strategies as necessary, and investigates
alternative technical or organizational solutions Manages
and utilizes an internal group database to track DNA
samples, primers, and genotypes. Maintains and tracks
new and current DNA samples. Uses a high level of discretion
to prioritize workflow and experimental methodologies.
Effectively communicates with all levels of staff to
optimize workflow and to solve problems.
Characteristic Duties:
• In consultation with project leader, designs
and carries out small independent projects.
• Ensures that the progress and results of various
experiments and projects adhere to project requirements
and team goals. Manages a database to compile and present
results in meaningful manner.
• Collaborates with project leader to analyze
results, to address complex technical problems, and
to assist with identifying team goals and priorities.
Documents, compiles, organizes and analyzes experimental
data by performing calculations, preparing graphic displays
and creating detailed spreadsheets; assists with interpreting
data to identify possible methodological problems.
• Continually aids in and adapts to the creation
of new and improved techniques in data analysis, experiment
design and implementation in an effort to optimize techniques
and lab protocols.
• Actively participates in all team meetings for
experimental planning and review, ensuring that all
projects support current team goals.
• May forecast and purchase materials and supply
needs as required by project details.
• Interacts with vendors and collaborators to
investigate novel supplies and technologies. Interacts
with all levels of staff to assist with evaluations
of new equipment.
• May train and supervise Technical Assistants
and other entry-level lab personnel in the design and
performance of smaller experiments and projects that
contribute to larger ongoing projects.
• Other tasks as required.
Qualifications:
• Bachelor’s degree and at least 2 years
of experience in a related field, Master’s degree
and 1 year of experience or equivalent combination of
education and experience required.
• Comfort working in the UNIX environment a plus.
• Previous experience with sequencing and Sequenom
genotyping a plus.
• Must possess a familiarity with basic molecular
biology techniques, sterile techniques, and the operation
of standard lab equipment.
• Excellent knowledge of computers and experience
with databases required.
• Excellent organization and time management skills.
• Must possess a high level of initiative and
the ability to work with little supervision.
Posted By: Dr. Pamela Sklar
Please email resumes/CVs and cover letters to Jarred
Knapp at:
jknapp@partners.org
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