Selected Publication

Center Publications

  1. Artavanis-Tsakonas K, Love JC, Ploegh HL, Vyas JM . Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proceedings of the National Academy of Science. 2006: p. In press.
  2. Arystarkhova E , Donnet C., Asinovski NK, Sweadner KJ. Splice variants of the gamma subunit differentially influence functional parameters of the Na,K-ATPase in kidney. J. Biol. Chem . 2002. 277:10162-10172
  3. Avruch J , Praskova M, Ortiz-Vega S, Liu M, Zhang XF. Nore1 and RASSF1 Regulation of Cell Proliferation and of the MST1/2 Kinases. Methods Enzymol. 2006;407:290-310.
  4. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY . (2006). Bone Morphogenetic Protein Signaling by Hemojuvelin Regulates Hepcidin Expression. Nature Genetics 38(5):531-9.
  5. Bennish ML, Khan WA, Begum M, Bridges EA, Ahmed S, Saha D, Salam MA, Acheson D, Ryan ET . Low risk of hemolytic uremic syndrome (HUS) following early effective antimicrobial therapy of Shigella dysenteriae type 1 infection in Bangladesh. Clin Infect Dis 2006;42:356-62.
  6. Bentires-Alj M, Gil SG, Chan R, Wang ZC, Imanaka N, Harris L, Richardson A, Neel BG , Gu H.  Casual role of the scaffolding adapter Gab2 in breast cancer. Nat Med. 2006; 12:114-121. Epub 2005 Dec 20.
  7. Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA . Downregulation of the vasopressin type 2 receptor (V2R) after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 288: C1390-C1401, 2005.
  8. Bromley SK, Thomas SY, Luster AD . CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol. 2005; 6: 895-901.
  9. Butler SM, Nelson EJ, Chowdhury N, Faruque SM, Calderwood SB , Camilli A. Cholera stool bacteria repress chemotaxis to increase infectivity. Mol Micro 2006; 60:417-426.
  10. Calvano SE, Xiao W, Richards DR, et al , Tompkins RG , Lowry SF. A network-based analysis of systemic inflammation in humans. Nature 2005;437:1032-7. Epub 2005 Aug 31. Erratum in: Nature 2005 Dec 1;438:696.
  11. Cariappa A, Mazo IB, Chase C, Shi HN, Liu HY, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S . Perisinusoidal B cells in the bone marrow mediate T independent IgM responses to blood-borne microbes. Immunity 2005, 23, 397-407.
  12. Cariappa A, Tang M. Parng C, Nebelitskiy E, Carroll MC, Georgopoulos K, Pillai S . The follicular versus MZ B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. 2001. Immunity, 14, 603-615
  13. Chakraverty R, Cote D, Buchli J, Cotter P, Hsu R, Zhao G, Sachs T, Pitsilldes C, Bronson R, Means T, Lin C, Sykes M. An Inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J. Exp. Med. 2006;203(8):2021-2031.
  14. Chen M, Pothoulakis C, Lamont JT . PKC signalling Z0-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J. Biol Chem, 277: 4247-4254, 2002.
  15. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O'Brien M, Pothoulakis C , Kelly CP . Saccharomyces boulardii inhibits ERK1/2 Mitogen-Activated Protein Kinase activation both in vitro and in vivo, and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006 Jun 30
  16. Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi . Concurrent infection of an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infection and Immunity . 2005. 73: 5468-5481.
  17. Chien-Chang Chen, Steve Louie, Beth McCormick, Allan Walker and Hai Ning Shi. Helminth primed dendritic cells alter the host response to enteric bacterial infection. The Journal of Immunology . 2006. 176: 472-483.
  18. Claud EC, Lu L, Anton PM, Savidge T, Walker WA , Cherayil BJ. Developmentally-regulated IkB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. PNAS 2004; 101(19):7404-7
  19. Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, Depierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD . PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006 Aug 20; [Epub ahead of print] PMID: 16921384
  20. Del Re E, Babitt JL, Pirani A, Schneyer AS, Lin HY . (2004). In the absence of the type III receptor, the TGF-beta type II receptor requires the type I receptor to bind TGF-beta 2. J. Biol Chem , 279(21):22765-22772.
  21. Ding Z, Bradley KA, Amin Arnaout M, Xiong JP . Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli . Protein Expr Purif . 2006 Sep;49(1):121-8. Epub 2006 Apr 28.
  22. Fudaba Y, Spitzer TR, Shaffer JM, Kawai T, Fehr T, Delmonico FL, Preffer FI, Tolkoff-Rubin, Dey BR, Saidman SL, Kraus A, Bonnefoix T, McAfee S, Power K, Kattelman K, Colvin RB, Sachs DH, Cosimi AB, Sykes M . Myeloma responses and tolerance following combined kidney and non-myeloablative marrow transplantation: in vivo and in vitro analyses. Am. J. Transplant. 2006;6:2121-2133.
  23. Hang L, John M, Asaduzzaman M, Bridges EA, Vanderspurt C, Kirn TJ, Taylor RK, Hillman JD, Progulske-Fox A, Handfield M, Ryan ET, Calderwood SB . Use of in vivo - induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae. Proc Natl Acad Sci USA 2003; 100:8508-8513.
  24. Harris JB, Baresch-Bernal A, Rollins SM, Alam A, LaRocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET. Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi. Infect Immun 2006; 74;5161-5168.
  25. Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE . Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation 2006;113:2301-12.
  26. Hellman J, Roberts JD, Tehan MM, Allaire J, Warren HS . Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in Gram-negative sepsis and causes inflammation and death in mice. J Biol Chem. 2002 Apr 19;277(16):14274-80.
  27. Hinnebusch B, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, Abedrapo MA, Chen X, Yang V, and Hodin RA . Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched krüppel-like factor. Am J Physiol , 2004;286:G23-G30
  28. Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper S, Terhorst C, Blumnerg RS, and Mizoguchi A : Induced reactivity of intestinal CD4 + T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity 2004, 20:681-693.
  29. Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA , Brown D, Marshansky V. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol. 8(2): 124-36, 2006.
  30. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, López-Otín C, Krane SM . Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci USA. 2004;101:17192-17197.
  31. Jain S, van Ulsen P, Benz I, Schmidt MA, Fernandez R, Tommassen J, Goldberg MB . Polar localization of the autotransporter family of large bacterial virulence proteins. J Bacteriol. 2006; 188:4841-4850.
  32. Janakiraman A, Goldberg MB . Evidence for polar positional information independent of cell division and nucleoid occlusion. Proc Natl Acad Sci USA. 2004; 101:835-840.
  33. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C . Induction of colitis causes inflammatory responses in mesenteric fat tissue: evidence for substance P-mediated pathways in human mesenteric preadipocytes. Proc Natl Acad Sci (USA), 2006; 103:5207-12.
  34. Keates AC , Keates S, Kwon JH, Arseneau KO, Law DJ, Bai L, Merchant JL, Wang TC, Kelly CP. ZBP-89, Sp1 and NF- k B regulate ENA-78 gene expression in Caco-2 human colonic epithelial cells. Journal of Biological Chemistry (2001);276:43713-43722.
  35. Kennedy AM, Inada M, Krane SM , Christie PT, Harding B, Lopez-Otin C, Sanchez LM, Pannett AA, Dearlove A, Hartley C, Byrne MH, Reed AA, Nesbit MA, Whyte MP, Thakker RV. MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD MO ). J Clin Invest. 2005;115:2832-2842.
  36. Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, and Lamont JT . Clostridium difficile Toxin A regulates inducible cyclooxygenase-2 and prostaglandin E 2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J. Biol. Chem., 280: 21237-21245, 2005
  37. Kim ND, Chou RC, Seung E, Tager AM, Luster AD . A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis. J Exp Med 2006; 203: 829-835.
  38. Kirley SD, D'Apuzzo M, Lauwers GY, Graeme-Cook F, Chung DC, Zukerberg LR . The Cables gene on chromosome 18Q regulates colon cancer progression in vivo. Cancer Biol Ther. 2005 Aug;4(8):861-3.
  39. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Sachs DH, Cooper DK. Localized myocardial infarction following pig-to-baboon heart transplantation. Xenotransplantation 2005; 12: 489-91.
  40. Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC . ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3a gene expression in Caco-2 human colonic epithelial cells. Journal of Biological Chemistry (2003) 278:875-884.
  41. LaRocque RC, Harris JB, Dziejman M, Li X., Khan AI, Faruque ASG, Faruque SM, Nair GB, Ryan ET, Qadri F, Mekalanos JJ, Calderwood SB . Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun 2005; 73: 4488-4493.
  42. Laudanski,K, Miller-Graziano C, Xiao W, Mindrinos M, Richards, D, De, A, Moldawer, L, Maier, R, Bankey, P, Baker, H, Brownstein, B, Cobb, JP, Calvano, S, Davis, R, Tompkins RG . Cell- Specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways PNAS e-pub 2006 Oct 9-13 (in process)
  43. Lesser, C.F. and Miller, S.I. (2001) Expression of microbial virulence factors in Saccharomyces cerevisiae models mammalian infection. EMBO 20 (8), 1840-9.
  44. Lesser, C.F. and Miller, S.I. (2001) Tractable Saccharomyces cerevisiae is model system for studying pathogenic bacterial proteins: introducing bacterial virulence proteins into yeast provides valuable insights about their interactions with host components. ASM News. 67(9), 448-455.
  45. Li, Q. and Cherayil, B.J. The role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella infection. Infect. Immun. 2003; 71: 4873-4882.
  46. Li, X., Shelley, C.S., Xiong, J-W and Arnaout, M.A. The ZBP-89 gene specifies hematopoietic stem cell development from FLK1+ mesoderm. 2006. Development. Sep;133(18):3641-50. Epub 2006 Aug 16.
  47. Liang C, Feng P, Ku, Dotan I, Canaani D, Oh B-H, Jung JU . Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nature Cell Biology 8:688-699, 2006.
  48. Merrell DS, Butler SM, Qadri F, Dolganov NA, Alam A, Cohen MB, Calderwood SB , Schoolnik GK, Camilli A. Host induced epidemic spread of the cholera bacterium. Nature 2002; 417:642-645.
  49. Mizoguchi A , Mizoguchi E, Takedatsu H, Blumberg RS, and Bhan AK: Chronic intestinal inflammatory condition generates IL-10 producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002, 16:219-230.
  50. Mizoguchi E , Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky D, Mizoguchi A. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 2003;125:148-61.
  51. Mizoguchi E . Chitinase 3-like-1 (CHI3L1) exacerbates acute intestinal inflammation by enhancing intracellular bacterial adhesion and invasion in colonic epithelial cells. Manuscript provisionally accepted for Gastroenterology, 2006:130:398-411.
  52. Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang XB, Zimmer MA, Iliopoulos O, Zukerberg LR, Lynch MP, Rueda BR, Chung DC . Induction of interleukin-8 preserves the angiogenic response in HIF-1 deficient colon cancer cells. Nature Medicine, 2005, 11:992-97.
  53. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge TC, Hurley BP, Madara JL, McCormick BA . Identification of hepoxilin A 3 in inflammatory events: A required role in neutrophil migration across the intestinal epithelia. Proc. Natl. Acad. Sci. USA 2004; 101: 7421-7426.
  54. Mylonakis E , Ausubel FM, Perfect JR, Heitman J, Calderwood SB. Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. Proc Natl Acad Sci USA 99:15675-80; 2002.
  55. Mylonakis E , Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB. Cryptococcus neoformans Kin1 protein kinase homolog, identified through a C. elegans screen, p romotes virulence in mammals. Mol Microbiol 54:407-19; 2004.
  56. Nagaishi T, Pao L, Lin S-H, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG , Blumberg RS.   SHP1 dependent T cell inhibition by CEACAM1 isoforms expressing a long cytoplasmic domain.  Immunity, accepted.
  57. Nanthakumar NN, Young C, Ko JS, Meng D, Chen J, Buie T, Walker WA . Glucocorticoid responsiveness in the developing human intestine: possible role in the prevention of necrotizing enterocolitis. AJP: GI and Liver Physiology 2005 288:G85-G92.
  58. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick B, Vyas JM, Boes M, Ploegh H, Fox J, Littman DR, Reinecker HC . Control of dendritic cell access to the intestinal lumen and of bacterial clearance by CX 3 CR1. Science. 14 Jan 2005; 307:254-258.
  59. Rhee S.J., Walker, W.A., and Cherayil, B.J. Developmentally-regulated intestinal expression of IFN g and its target genes and the age-specific response to enteric Salmonella infection. J. Immunol. 2005; 175: 1127-1136.
  60. Rhee SH, Im E, Riegler M, Kokkotou M, O'Brien M, Pothoulakis C . Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci (USA), 2005; 102:13610-5.
  61. Roig J, Groen A, Caldwell J and Avruch J . Active Nercc1 protein kinase concentrates at  centrosomes early in  mitosis and is necessary for proper spindle assembly. Mol. Biol. Cell. 2005;16: 4827-4840.
  62. Rollenhagen JE, Kalsy A, Cerda F, John M, Harris JB, LaRocque RC, Qadr F, Calderwood SB, Taylor RK, Ryan ET . Transcutaneous immunization with toxin co-regulated pilin A (TcpA) induces protective immunity against Vibrio cholerae O1 El Tor challenge in mice. Infect Immun. (in press).
  63. Sabatine MS, Liu E, Morrow DA, Heller E, McCarroll R, Wiegand R, Berriz GF, Roth FP, Gerszten RE . Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation 2005;112:3868-75.
  64. Salazar-Gonzalez RM, Niess JH, Zammit DJ, Ravindran R, Srinivasan A, Maxwell JR, Stoklasek T, Yadav R, Williams IR, Gu X, McCormick BA, Pazos MA, Vella AT, Lefrancois L, Reinecker HC , McSorley SJ. CCR6-Mediated Dendritic Cell Activation of Pathogen Specific T cells in Peyer's patches. Immunity. 2006 May; 24(5): 623-632.
  65. Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters PA, Travers SB, Blank MA, van Deventer SJ. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med. 2004;350(9):876-85
  66. Schneeberger, EE and Lynch RD. The tight junction: A multifunctional complex. Am J Physiol: Cell Physiol 2004; 286:C1213-C1228.
  67. Sever S , Newmyer S, Skoch J, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT and Bacskai BJ. The co-chaperon auxilin is required for clathrin-coated vesicle formation during endocytosis. EMBO J. 2006. 25:4163-74
  68. Sougioultzis S, Kyne L, Drudy D, Keates S, Maroo S, Pothoulakis C , Giannasca PJ, Lee CK, Warny M, Monath TP, Kelly CP . Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology. 2005;128:764-70.
  69. Stuart LM , J Boulais, EJ Hennessy, GM Charriere , S Brunet, I Jutras , G Goyette , C Rondeau , S Letart , H Huang, P Ye, F Morales , C Kocks, JS Bader, M Desjardins and RAB Ezekowitz. "A systems biology analysis of the Drosophila phagosome". (Nature, in press)
  70. Tavakkolizadeh, A., U. V. Berger, K. R. Shen, L. L. Levitsky, M. J. Zinner, M. A. Hediger, S. W. Ashley, E. E. Whang, and D. B. Rhoads . Diurnal rhythmicity in intestinal SGLT-1 function, V max , and mRNA expression topography. Am J Physiol 280: G209-15 (2001)
  71. Wang, L., C. Coffinier, M. K. Thomas, L. Gresh, G. Eddu, T. Manor, L. L. Levitsky, M. Yaniv, and D. B. Rhoads . Selective deletion of the Hnf1b (MODY5) gene in b cells leads to altered gene expression and defective insulin release. Endocrinology 145:3941-3949 (2004) Epub 2004 May 13
  72. Warren HS , Suffredini AF, Eichacker PQ, Munford RS. Risks and benefits of activated protein C treatment for severe sepsis. New Eng. J. Med. 2002; 347:1027-1030 (Sounding Board)
  73. Wetzel RK, Pascoa JL, Arystarkhova E . Stress-induced Expression of the {gamma}Subunit (FXYD2) Modulates Na,K-ATPase Activity and Cell Growth. J. Biol. Chem. 2004; 279: 41750-41757.
  74. Wong BS, Yamada K, Okumi M, Weiner J, O'malley PE, Tseng YL, Dor FJ, Cooper DK, Saidman SL, Griesemer A, Sachs DH . Allosensitization Does Not Increase the Risk of Xenoreactivity to alpha1,3-Galactosyltransferase Gene-Knockout Miniature Swine in Patients on Transplantation Waiting Lists. Transplantation. 2006 Aug 15;82(3):314-319.
  75. Wu JT, Archer SY, Hinnebusch B, Meng S, Hodin RA . Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. Am J Physiol 2001;280:G482-G490
  76. Wu, J.Y., Jin, Y-Z, Edwards, R.A., Zhang, Y., Finegold, M.J., and Wu, M.X . (2005). Impaired TGF-beta responses in peripheral T cells of Gai2-/- mice. J. Immunol. 174:6122.
  77. Xiong, J.P., Stehle, Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., and Arnaout, M.A . Crystal Structure of the Extracellular Domain of Integrin aVb3 in complex with an Arg-Gly-Asp ligand. 2002. Science . Apr 5;296(5565):151-155.
  78. Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Schuurman HJ, Awwad M, Sykes M, Sachs DH . Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1, 3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32-4.
  79. Yuan Q , GS Campanella, RA Colvin, DL Hamilos, KJ Jones, A Mathew, TK Means, and AD Luster. Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in interleukin-4 stimulated epithelial cells. Eur J Immunol (In press).
  80. Yuan Q , TK Means, KJ Jones, F Hayashi, AK Bhan, and AD Luster. CCR-4 Dependent Regulatory T cell Function in Inflammatory Bowel Disease. J Exp Med (submitted).
  81. Zhang, Y., Schlossman, S. F., Edwards, R. S., Ou, Ching-Nan, Gu, J., and Wu, M. X. (2002). Impaired apoptosis, extended duration of immune responses and a lupus- like autoimmune disease in IEX-1-transgenic mice. Proc. Natl. Acad. Sci. USA. 99: 878-883 (Track II submission).