| Days of Molecular Medicine 2008 |
| Cognitive Dysfunction in Disease: Mechanisms and Therapies |
| The Karolinska Institutet |
| Berzelius väg 3 / Adams Hall |
| Stockholm, Sweden |
| April 17 -19, 2008 |
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| EVENT PROGRAM |
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| THURSDAY, APRIL 17TH |
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| 12:30 PM |
Registration |
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| 2:00 - 2:30 PM |
Opening Remarks |
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Chair: Hans Forssberg, Vice President, Karolinska Institutet |
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Harriet Wallberg-Henriksson, President, Karolinska Institutet |
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Joseph Martin, Dean Emeritus, Harvard Medical School |
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Emilie Marcus, Cell Press |
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Katja Brose, Cell Press |
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| 2:30 - 3:30 PM |
Keynote Address |
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Chair: Sten Grillner, Karolinska Institutet |
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Eric Kandel |
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Columbia University |
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Mice, Men and Mental Illness: Models of Human Psychiatric Disorders in Mice |
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| 3:30 - 4:00 PM |
Break |
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Session I: Cognitive Functions and their Cellular Bases |
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Session I, Part A: Cognitive Functions |
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Chairs: Lars-Göran Nilsson, Stockholm University and Stockholm Brain Institute |
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| 4:00 - 4:30 PM |
Daniel Schacter |
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Harvard University |
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Constructive Memory: Linking Past and Future |
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| 4:30 - 5:00 PM |
Sabine Kastner |
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Princeton University |
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Neural Basis of Visual Attention |
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| 5:00 - 5:30 PM |
Ray Dolan |
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University College London |
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The Influence of Emotion on Decision Making |
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| 7:30 PM |
Welcome Reception |
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Stockholm Town Hall |
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| FRIDAY, APRIL 18TH |
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Session I, Part B: Cellular Mechanisms of Cognition |
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Chair: Ole Kiehn, Karolinska Institutet |
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| 8:30 - 9:00 AM |
Isabelle Mansuy |
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University of Zurich |
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Epigenetics of Learning and Memory |
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| 9:00 - 9:30 AM |
Bruce McEwen |
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Rockefeller University |
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Stress, Sex and Cognitive Processes: Role of Neuronal Remodeling |
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| 9:30 - 10:00 AM |
Alcino Silva |
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University of California at Los Angeles |
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Molecular and Cellular Cognition: Unraveling Mechanisms and Finding Cures for Learning Disabilities |
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| 10:00 - 10:30 AM |
Mark Bear |
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Massachusetts Institute of Technology |
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Modification of Cerebral Cortex by Experience |
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| 10:30 - 11:00 AM |
Break |
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Session II: Cognitive Dysfunctions in Psychiatric and Neurological Disorders |
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Session II, Part A: Neurodevelopmental Disorders |
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Chairs: Anna Wedell, Karolinska Institutet |
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Ivanka Savic, Karolinska Institutet and Stockholm Brain Institute |
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| 11:00 - 11:30 AM |
Nancy Pedersen |
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Karolinska Institutet |
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The Changing Role of Genes for Cognitive Decline and Dementia |
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| 11:30 - Noon |
Daniel Geschwind |
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University of California, Los Angeles |
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Autism: From Genes to Brain |
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| Noon - 12:30 PM |
Matthew State |
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Yale University School of Medicine |
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Genetics of Tourette Syndrome and Obsessive Compulsive Disorder |
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| 12:30 - 3:00 PM |
Lunch + Poster Session |
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Session II, Part B: Schizophrenia, Bipolar and Other Mood Disorders |
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Chairs: Torgny Svensson, Karolinska Institutet |
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| 3:00 - 3:30 PM |
Trevor Robbins |
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University of Cambridge |
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Modeling Cognitive Deficits in Schizophrenia |
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| 3:30 - 4:00 PM |
Daniel Weinberger |
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National Institute of Mental Health |
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Schizophrenia: From Genes to Brain |
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| 4:00 - 4:30 PM |
Lars Farde |
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Karolinska Institutet |
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Molecular Biomarkers in Schizophrenia |
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| 4:30 - 5:00 PM |
René Hen |
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Columbia University |
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Hippocampal Neurogenesis and Depression |
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| 7:00 PM |
Conference Dinner |
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Stockholm Modern Museum |
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| SATURDAY, APRIL 19TH |
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Session II, Part C: Neurodegenerative Disorders |
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Chairs: Joseph Martin, Harvard University Medical School |
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Bengt Winblad, Karolinska Institutet |
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| 8:30 - 9:00 AM |
James Gusella |
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Massachusetts General Hospital |
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A Genetics-Directed Strategy for Target Identification: The
Huntington's Disease Paradigm |
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| 9:00 - 9:30 AM |
Karen Ashe |
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University of Minnesota |
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| Human Relevance of a Common Alzheimer Mouse Model |
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| 9:30 - 10:00 AM |
Ted Dawson |
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Johns Hopkins University School of Medicine |
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Molecular Mechanisms of Neurodegeneration in Parkinson’s Disease |
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| 10:00 - 10:30 AM |
Adriano Aguzzi |
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University Hospital of Zürich |
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Molecular Systems Biology of Prions |
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| 10:30 -11:00 AM |
Break |
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Session III, Part A: Interventional Approaches |
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Chair: Ola Hermansson, Karolinska Institutet |
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| 11:00 - 11:30 AM |
Adrian Bird |
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University of Edinburgh |
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Reversibility of Rett Syndrome |
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| 11:30 - Noon |
Ole Isacson |
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Harvard Medical School |
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Therapeutic Effects of Cell and Engineered Stem Cell Derived Neurons in Neurodegenerative Diseases |
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| Noon - 12:30 PM |
Lars Lannfelt |
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Uppsala University |
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Soluble Amyloid-Beta Protofibrils as Pathogenic Species in Alzheimer’s Disease |
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| 12:30 - 3:00 PM |
Lunch + Poster Session |
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| 3:00 - 3:30 PM |
Special Lecture |
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Chair: Lars Farde, Karolinska Institutet / AstraZeneca |
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Jackie Hunter |
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GlaxoSmithKline |
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The Challenges Of Drug Discovery And Development In Neurodegeneration |
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| 3:30 - 4:00 PM |
Discussion / Panel |
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Michael Hehenberger, IBM and Mark Bear, Massachusetts Institute of Technology |
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| 4:00 - 4:15 PM |
Break |
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Session III, Part B: Interventional Approaches |
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Chairs: Zsuzsanna Wiesenfeld-Hallin, Karolinska Institutet |
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| 4:15 - 4:45 PM |
Torkel Klingberg |
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Karolinska Institutet |
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Computerized Training of Working Memory in Children with ADHD |
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| 4:45 - 5:15 PM |
Karl Deisseroth |
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Stanford University |
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Optogenetics: Technology Development and Neuropsychiatry Application |
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| 5:15 - 5:45 PM |
Helen Mayberg |
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Emory University |
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Modulating Putative Depression Circuits using Deep Brain Stimulation |
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| 5:45 - 6:00 PM |
Concluding Remarks |
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