Explore current research projects at Mass General.
Cancer Center
Massachusetts General Hospital Cancer Center is committed to eradicating cancer and is fueled by scientific investigation conducted as part of the largest hospital-based research program in the United States.
Cardiovascular Research Center
The Cardiovascular Research Center (CVRC) at Massachusetts General Hospital was founded in 1990 to bridge the gap between the science of heart disease and the practice of cardiovascular medicine.
CCIB
The Massachusetts General Hospital Center for Computational and Integrative Biology is an affiliation of faculty drawn together by a common interest in the study of biology through methods engaging a broader scale of inquiry than the existing standard.
Center for Human Genetic Research
The Massachusetts General Hospital Center for Human Genetic Research is a multidisciplinary crossdepartmental center with the central mission of facilitating the genetic research cycle.
Center for Regenerative Medicine
The Center for Regenerative Medicine is dedicated to understanding how tissues are formed and may be repaired in settings of injury and disease.
Center for Systems Biology
The goal of the Massachusetts General Hospital Center for Systems Biology is to analyze, at a systems level, how biological molecules, proteins and cells interact in both healthy and diseased states.
Center for Translational Pain Research
The Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic, and cancer pain conditions by using a multidisciplinary and mechanism-based research approach to clinical pain management together with basic science pain research.
Cutaneous Biology Research Center
To achieve that goal the CBRC maintains an environment conducive to collaboration with industrial partners to disseminate the fruits of fundamental research from the CBRC.
Vincent Center for Reproductive Biology
The VCRB consists of basic and clinical scientists whose primary research emphasis includes infertility, aging and cancer as they pertain to the ovary and uterus. The center provides an optimal environment for individuals who are interested in integrating clinical and basic sciences and have a strong desire to pursue a career in academic research.
Wellman Center for Photomedicine
The Wellman Center for Photomedicine at Massachusetts General Hospital investigates the effects of light on human biology and develops light-mediated, minimally invasive diagnostic and therapeutic technologies.
Alexander G. Marneros, M.D., Ph.D.
Angiogenesis in development and disease
Arlotta Lab
The genetic programs that control the differentiation of distinct types of neurons in the brain are still largely unknown. In our lab we address this issue in the mammalian cerebral cortex and our main interest focuses on understanding and investigating the molecular pathways that direct the early specification of progenitors to generate distinct types of projection neurons during development. We specifically focus on the early signals that induce differentiation of corticospinal neurons, a clinically relevant neuronal target population that in humans selectively degenerates in ALS (Lou Gehrig’s disease), Hereditary Spastic Paraplegia (HSP), Primary Lateral Sclerosis (PLS), and that is permanently injured in spinal cord injury.
Arthroscopic Psychomotor Skills Laboratory
The Arthroscopic Psychomotor Skills Laboratory provides an opportunity for development in operating techniques using Arthroscopic instruments.
Bardeesy Lab
Research topics include: pancreatic ductal adenocarcinoma
Behavioral Medicine Service
The Behavioral Medicine Services include clinical, research, and training activities that focus on the intersection of psychology and health.
Bernards Lab
Research topics include: Neurofibromatosis-1 (NF1)
Bernstein Lab
Research topics include: chromatin; stem Cells; genomics; polycomb; epigenetics
Bioengineering Laboratory
The Bioengineering Laboratory, under the direction of Guoan Li, PhD, continues its tradition of innovation in the area of joint engineering and biomechanics.
Biomaterials Research Laboratory
This Laboratory provides unique opportunities for scientists, residents, fellows and staff and is an integral part of the future of Orthopaedic Research at Mass General.
Bone Marrow Transplant Clinical Research
The clinical mission of the Bone Marrow Transplant Clinical Research Lab is to provide a comprehensive range of transplant-related services to patients with hematologic malignancies and other potentially life-threatening blood dyscrasias. Its research mission is to develop novel methods of allogeneic stem cell transplantation to maximize the separation of graft versus host disease (GVHD) and graft versus tumor (GVT) effect in both the HLA-matched and mismatched settings.
Boucher Lab
As part of the Edwin L. Steele Laboratory for Tumor Biology, the Boucher Laboratory analyzes delivery of oncolytic viruses and large therapeutic agents in tumors and tumor cell migration and metastasis.
Brack Lab
Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.
Brack Lab
Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.
Breast Cancer Clinical Research
Our program is on the forefront of investigation to find better therapies, improve diagnostics, and develop less invasive, breast-sparing surgical techniques for the treatment of breast cancer.
Bruce A. Morgan, Ph.D
Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital
Cardiac Anesthesia Lab
Research within the Cardiac Anesthesia Lab at Massachusetts General Hospital advances the evolving field of cardiac anesthesiology and improves outcomes for both adult and pediatric patients.
Cardiac MR PET CT Lab
The Cardiac MR PET CT Lab at Massachusetts General Hospital has built a tremendous expertise in all aspects of cardiovascular imaging research over the last years.
Cardiac Surgery Lab
Cardiac surgery research at the Massachusetts General Hospital Heart Center offers patients the most promising therapies based on the latest scientific evidence.
Cardiovascular Clinical Research Lab
The Cardiovascular Clinical Research Lab seeks to improve clinical diagnosis and treatment of cardiovascular diseases.
Cartilage Biology and Orthopaedic Oncology Laboratories
The Orthopaedic Oncology Laboratory seek factors that may serve as predictors of metastasis in malignant bone and soft tissue tumors both by molecular and biochemical studies and by flow cytometric analyses of DNA ploidy and cell cycle parameters.
Cellular & Molecular Radiation Oncology Laboratory
Working at the cellular and molecular levels, our studies cover a range of topics, including mechanisms of cell death, DNA damage induction and repair processes, bystander effects, and cancer genetics.
Center for Addiction Medicine
The MGH-Harvard Center for Addiction Medicine delivers clinical evaluation, consultation, and study-related clinical care in a multidisciplinary setting.
Center for Anxiety & Traumatic Stress Disorders
The mission of the Center for Anxiety and Traumatic Stress Disorders (CATSD) is to conduct state-of-the-art research aimed at improving the standard of care for people suffering from anxiety disorders.
Center for Applied Clinical Investigation
The Center for Applied Clinical Investigation (CACI) is a training and research center where scientific rigor is used to examine clinical practice and to determine risks and outcomes associated with the variables that comprise patient care.
Center for Cancer Risk Assessment Clinical Research
The Center for Cancer Risk Assessment (CCRA) is devoted to the integration of molecular genetics and the clinical study of cancer predisposition. The Center has both laboratory and clinical components.
Cerebral Amyloid Angiopathy Research Lab: Steven M. Greenberg, MD, PhD
Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.
Chemical Genomics of Neuropsychiatric & Neurological Disease - Haggarty Laboratory
The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.
Chung Lab
The main research interest of the Chung Laboratory has been studies of the biology of hepatitis C virus infection, the leading cause of chronic viral liver disease in the U.S.
Chung Lab
The overall goal of the Chung Laboratory is to better elucidate the genetic events in gastrointestinal tumorigenesis.
Classon Lab
Research topics include: the role of the pRB pathway and the pRB family of proteins (pRB, p107 and p130) in tumorigenesis
Clinical Trials Network & Institute (CTNI)
The MGH Psychiatry CTNI is part of the MGH Psychiatry Department, one of the leading academic research programs in the world - with over $35 million in research programs last year alone. Our department has extensive experience over the past 25 years in industry-sponsored multi-center clinical trials.
Cognitive Behavior Therapy (CBT)
The mission of the Cognitive Behavior Therapy (CBT) Program is to inform and educate healthcare professionals, students, and the general public about CBT, further CBT research, and provide advanced clinical care to patients in the context of CBT.
Cortical Physiology Laboratory - Sydney S. Cash, MD, PhD
We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.
Cosmas Giallourakis's Laboratory
We study genetics of intestinal diseases.
Cowan Lab
Our research is focused on understanding the contribution of environmental and genetic factors in the development of disease. We are building in vitro models using human embryonic stem cells, in which genetic and developmental aspects of the disease can be controlled.
Cusack Lab
Research topics include: overcoming anti-apoptotic responses to chemotherapy and irradiation
Daniel Chung's Laboratory
Our project will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been non-responders or ineligible to receive current treatments.
Davidson Lab
Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.
Depression Clinical & Research Program (DCRP)
The DCRP is considered one of the leading centers for the study of Unipolar Depressive Disorders worldwide.
Di Tomaso Lab
Research topics include: vaascular physiology of neurofibromatosis type 2 tumors
Diabetes Research | David Altshuler, MD PhD
The Alshuler lab focuses on studies of human genome sequence variation as a route to understanding the inherited basis of common human diseases, with a major focus on type 2 diabetes.
Diabetes Research Center
The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.
Diabetes Research Center - Clinical and Translational Research
For over two decades, the Mass General Diabetes Clinical Research Center has developed and evaluated innovative therapies for Type 1 and Type 2 diabetes.
Diabetes Unit Type 2 Diabetes Laboratory
The Type 2 Diabetes Laboratory focuses on studies relating to insulin resistance in type 2 diabetic patients.
Division of Nephrology Research Program
The Division of Nephrology's research programs are directed towards the elucidation of basic cellular mechanisms and the causes, management and potential therapies of kidney disease.
Dr. Rodrigo Mora Laboratory
Understanding the impact of leukocyte trafficking in gastrointestinal and systemic immunity and its implications for immune responses
Dr. Snapper's Lab
Our laboratory is broadly interested in cell signaling pathways that regulate immune cells and epithelial cells in health and disease and the role of host: microbial cytoskeletal interactions in microbial pathogenesis.
Duda Lab
Research topics include: solid tumor cellular biology; bone marrow-derived cells in tumor angiogenesis and cancer progression.
Dyson Lab
Research topics include: E2F - and pRB-; tumorigenesis
Eating Disorders Clinical & Research Program
Our mission is to provide and to model excellent clinical care for patients and families affected by an eating disorder. The MGH Eating Disorders Clinical and Research Program is also committed to the generation and dissemination of knowledge for understanding, preventing, and treating eating disorders through clinical consultation, professional training, and research.
Edwin L. Steele Laboratory for Tumor Biology
The Edwin L. Steele Laboratory is committed to improving the prevention, detection and treatment of cancer in patients through a better understanding of tumor pathophysiology and host-tumor interactions.
Ellisen Lab
Research topics include: P53 and human tumorigenesis; breast cancer
Emergency Medicine Network
The Emergency Medicine Network's (EMNet) mission is to advance public health objectives through multicenter, emergency department-based research.
Endocrine Cancers Clinical Research
The Program in Endocrine Malignancies is dedicated to the diagnosis and therapy of benign and malignant tumors of the endocrine glands. The physicians affiliated with this center have expertise in the diagnosis and treatment of benign and malignant tumors of the thyroid, parathyroid, and adrenal glands as well as the tumors of the endocrine pancreas.
Endocrine Unit Research
Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.
Endocrine Unit: Bastepe Laboratory
The Bastepe Laboratory investigates the role of the GNAS locus and its gene products in physiology and disease pathogenesis.
Endocrine Unit: Demay Laboratory
The Demay Laboratory is focused on understanding the role of the Vitamin D receptor in hair follicle biology and actions of this receptor that are required to prevent alopecia and promote skin homeostasis. In addition, investigations are being performed to examine the role of phosphate in endochondral bone formation and in the prevention of rickets.
Endocrine Unit: Divieti Pajevic Laboratory
The Divieti Pajevic Laboratory of the Endocrine Unit investigates the complex interactions involved in bone metabolism.
Endocrine Unit: Gori Laboratory
The Gori Laboratory Studies bone development and metabolism in animal models.
Endocrine Unit: Kobayashi Laboratory
The Kobayashi Laboratory investigates the genetics of skeletal development.
Endocrine Unit: Kronenberg Laboratory
The Kronenberg Laboratory uses genetically altered mice to understand the roles of the PTH/PTHrP receptor in bone development, physiology, support of hematopoiesis, and disease.
Endocrine Unit: Mannstadt Laboratory
Research in the Mannstadt Laboratory focuses on diseases of the parathyroid glands.
Endocrine Unit: Neer Laboratory
Our research concerns the causes, diagnosis, prevention, and cure of osteoporosis, osteomalacia, and other metabolic bone diseases and focuses on the translation of laboratory advances to clinical medicine.
Endocrine Unit: Shimada Laboratory
The Shimada Laboratory of the Endocrine Unit investigates the complex interactions involved in bone development and remodeling.
Endocrine Unit: Shimada Laboratory
The Shimada Laboratory investigates bone development and remodeling.
Engelman Lab
Research topics include: lung cancer; targeted therapies; molecular fingerprinting
Ethan A. Lerner, M.D., Ph.D.
Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital
Fernandez-Del Castillo Lab
The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.
Fisher Lab
Our group studies cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood. We attempt to understand critical modes of cell homeostasis with a goal of molecular targeted therapy as well as prevention of melanoma and other human cancers
Fukumura Lab
Research topics include: nitric oxide; angiogenesis; tumor microcirculation; intravital microscopy; tumor microenvironment
Garkavtsev Lab
Research topics include: mechanisms governing the development of brain tumors
Gastrointestinal Cancers Clinical Research
The Tucker Gosnell Center for Gastrointestinal Cancers is the first center of excellence in the Harvard system that focuses on integrated multidisciplinary care and research for hepatic and biliary malignancies.
Geijsen Lab
My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.
Genitourinary Cancers Clinical Research
The clinical research program of the Claire and John Bertucci Center for Genitourinary Cancers is a multidisciplinary effort to understand cancer biology, discover novel agents and improve treatment outcomes for patients with genitourinary malignancies including cancers of the prostate, bladder and kidney.
Geriatric Education Center Grant
Chronic Care Educational Resource Training Project, Teaching Trainees how to Better Communicate with Older Adults Living with Chronic Disease
Gian Paolo Dotto, M.D., Ph.D.
G. Paolo, Dotto, MD, PhD Professor Massachusetts General Hospital Cutaneous Biology Research Center Building 149, 13th Street Charlestown, MA 02129 Tel: (617) 724-9538 Fax: (617) 726-9572 Email: gdotto@partners.org
Grabowski Lab
Research topics include: endothelial cell function; imaging platelet thrombosis; blood rheology and thrombosis; hemolytic uremic syndrome
Gynecologic Cancer Clinical Research
The Gillette Center for Gynecologic Oncology has become one of the nation's outstanding centers for clinical research in gynecologic malignancy. The center has had a strong leadership role at every level of development of therapies for women's cancers, from preclinical drug development, to Phase I and II trials, to Phase III cooperative clinical trials.
Haber Lab
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer
Haigis Lab
Research topics include: colon cancer; mouse models; Ras signaling; targeted therapy; systems biology
Harris Orthopaedic Biomechanics and Biomaterials Laboratory (HOBBL)
The Harris Orthopaedic Biomechanics and Biomaterials Laboratory (HOBBL) is under the co-direction of Orthun Muratoglu, PhD, and Henrik Malchau, MD, PhD. Members of this laboratory have contributed to the field of Adult Reconstructive Surgery for over four decades.
Hart Lab
Research topics include: modeling neurodegenerative disease in C. elegans; notch signaling in the adult nervous system; osmotic stress response and aging; quiescence and sensory signaling; lipid homeostasis
Harvard Program in Refugee Trauma
The Harvard Program in Refugee Trauma has spent 25 years caring for the health and mental needs of survivors of mass violence and torture through a combined practice of clinical experience and medical research.
Harvard Reproductive Endocrine Sciences Center
Supported by the National Institute of Child Health and Human Development (NICHD) for close to two decades, the Harvard Reproductive Endocrine Sciences Center builds and sustains the careers of investigators interested in the field of reproductive science.
Head & Neck Cancers Clinical Research
The Center for Head and Neck Cancers is a longstanding multidisciplinary clinical and scientific program that arose from a foundation established by world-renowned clinicians at Massachusetts General Hospital (MGH) and the Massachusetts Eye & Ear Infirmary (MEEI).
Held Lab
Research topics include: apoptosis; DNA damage and repair; oxidative stress; radiation-induced bystander effects; heavy ion radiation biology
Hematologic Malignancies Clinical Research
The Hematologic Malignancies Program encompasses research regarding leukemia, lymphoma and multiple myeloma, incorporating a substantial commitment to the understanding and use of stem cells in these diseases. It is closely integrated with the Bone Marrow Transplant Program, sharing commitment, faculty and research efforts.
Hochedlinger Lab
Research topics include: pluripotency and nuclear reprogramming
Hochedlinger Lab
Our lab tries to understand the role stem cells play in normal development and disease.
Hock Lab
Research topics include: transcription factors in blood development and leukemia
Hock Lab
Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.
Hodin Lab
The major focus of the laboratory is to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia.
Huang Lab
Research topics include: spontaneous tumors and their isograft models; histopathology; pathophysiology
Iliopoulos Lab
Research topics include; biology of tumor suppressor genes and tumor angiogenesis
International Division
The mission of the Division of International Psychiatry at MGH is to make clinical, educational and research contributions to world mental health and to help reduce the global burden of disease by learning from our neighbors and by contributing what we know to better relieve the suffering from mental illnesses around the world.
Jain Lab
Research topics include: tumor microenvironment; angiogenesis and lymphangiogenesis; metastasis; in vivo imaging; translational research; drug delivery, nanotechnology, mathematical modeling
Janice L. Brissette, Ph.D.
Associate Professor, Harvard Medical School Associate Biologist, Massachusetts General Hospital
Jin Mo Park , Ph.D.
Assistant Professor of Dermatology Harvard Medical School Assistant Biologist (Dermatology) Massachusetts General Hospital
Joung Lab
Research topics include: zinc fingers; zinc finger nuclease; gene targeting
Katia Georgopoulos, Ph.D.
Katia Georgopoulos, Ph.D. Professor of Dermatology Harvard Medical School Biologist (Dermatology) Massachusetts General Hospital
Kristin White, Ph.D.
Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital
Kuter Lab
Research topics include: thrombopoietin; thrombocythemia
Laboratory for Lipid Medicine and Technology
The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.
Laboratory for Neuroanatomy and Cerebellar Neurobiology, Jeremy D. Schmahmann, MD
I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.
Laboratory of Gastrointestinal Epithelial Biology
The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota.
Laboratory of Molecular Endocrinology
The Laboratory of Molecular Endocrinology conducts basic research to discover the causes of diabetes and potential cures for the disease.
Laboratory of Orthopaedic Biochemistry and Osteoarthritis Therapy
The overall mission of this laboratory is to understand the molecular mechanisms underlying the loss of extracellular matrix function that occurs in cartilage during degenerative arthritis.
Lamont Lab
Research topics include: clinical epidemiology and health services research in cancer
Langenau Lab
Uncovering downstream molecular pathways that regulate self-renewal as a step toward identifying novel therapies for the treatment of cancer.
Laurel A. Raftery, Ph.D.
Associate Professor of Dermatology Harvard Medical School Associate Biologist (Dermatology) Massachusetts General Hospital
Lipid Metabolism Unit
Research in the Lipid Metabolism Unit focuses on the role of lipids and lipoproteins in atherosclerosis.
Louis Lab
Research topics include: glioma; glioblastoma; molecular genetics; molecular pathology; therapeutics
Maheswaran Lab
Research topics include: tumorigenesis; breast cancer; cancer genetics
Major Depressive Disorder Study
Have you been feeling down or depressed lately? If so, do you have unusual experiences where it seems that people are out to give you a hard time or to hurt you; do you hear, see, feel, smell, or taste things that other people do not experience?
Masa Osawa, PhD
Assistant Professor of Dermatology, Harvard Medical School. Assistant Biologist, Cutaneous Biology Research Center Center for Regenerative Medicine, Massachusetts General Hospital
Mass General Epilepsy Research Laboratory, Daniel Hoch, MD, PhD, and Sydney S. Cash, MD, PhD
The Mass General Epilepsy Research Laboratory researches the anatomical, biochemical and physiological consequences of abnormal neuronal activity.
MassGeneral Institute for Neurodegenerative Disease (MIND)
The MassGeneral Institute for Neurodegenerative Disease (MIND) is poised to change the future for people with Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute was established to accelerate research discoveries that will lead to treatment and cures – sooner, rather than later.
McClatchey
Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity
Melanoma Clinical Research
The Center for Melanoma draws upon the specialized expertise of physicians and researchers from the Departments of Dermatology and Radiation Oncology, and the Divisions of Surgical Oncology, Transplant Surgery, Hematology and Oncology, and Dermatopathology.
Michael Choi Laboratory
Regulation of gut development and its relationship to peptic ulcer disease, colitis, and cancer
Michael Choi's Laboratory
Regulation of gut development and its relationship to peptic ulcer disease, colitis, and cancer
Mizoguchi Lab
Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.
Molecular Neurobiology Laboratory: Michael A. Schwarzschild, MD, PhD
The Schwarzschild lab targets three purines — adenosine, caffeine and urate — in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.
Mostoslavsky Lab
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair
Munn Lab
Research topics include: leukocyte mechanics and tumor physiology
Murat Bastepe, MD, PhD
Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.
Naar Lab
Research topics include: molecular mechanisms of gene regulation; the function of co-activators and co-repressors in mediating the action of transcription regulators
Neuroendocrine Clinical Research Program
Learn more about clinical research in the Neuroendocrine Unit at Mass General.
Neuroendocrine Malignancies Clinical Research
The Neuroendocrine Center is one of the premier multidisciplinary clinical and research programs in neuroendocrinology and pituitary tumors in the USA. A recognized international referral center, the Neuroendocrine Center incorporates multidisciplinary expertise from Neuroendocrinology, Neurosurgery, Neurology, Radiation Oncology and Psychiatry.
Neuroendocrine Research Laboratory
Learn more about basic research the the Neuroendocrine Unit at Mass General.
Neurology Clinical Trials Unit
The Neurology Clinical Trials Unit (NCTU) staff works with patients of Mass General-and their families-to inform them about clinical research studies conducted at Mass General and affiliated organizations.
Neuro-Oncology Clinical Research
The Stephen E. and Catherine Pappas Center for Neuro-Oncology is a national leader in clinical research and the development of experimental therapeutics for adult malignant brain tumors.
Ongoing Research
The Geriatric Research Unit at Mass General is largely involved in physiological research. Our research is mainly endocrine in nature with two major ongoing projects that are focused on glucose intolerance and muscle changes with aging.
Outcomes Research Center
Research at the Outcomes Research Center at Massachusetts General Hospital focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.
Padera Lab
Research topics include: the pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis
Pediatric Cancer Clinical Research
The Center for Pediatric Hematology and Oncology is actively participating in clinical trials and translational research. A significant number of our clinical trials are through collaborative efforts with the Children's Oncology Group (COG), the Pediatric Brain Tumor Consortium (PBTC), the New England Retinoblastoma Group and the Hodgkin Lymphoma Consortium.
Pediatric Epilepsy Research Lab: Kevin J. Staley, MD
The Pediatric Epilepsy Research Lab studies how neuronal ion transport and synaptic plasticity alter the spread of epileptic activity in neural networks.
Pediatric Psychopharmacology Clinical & Research Program
Our goal is to advance the well being of children and families afflicted with mental illness through clinical care, education and research.
Physics Research for Radiation Oncology
Research efforts are focused on developing radiation treatment techniques to optimize physical dose conformation to the tumor target volume and to increase the precision of the dose application.
Pillai Lab
"Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia"
Plastic Surgery Research Laboratory
The Plastic Surgery Research Laboratory conducts investigations into tissue engineering of cartilage, mechanisms of neural injury and regeneration, ischemia/reperfusion injury, and transplantation of vascularized limb tissues.
Program in Glomerular Disease
The MGH Program in Glomerular Disease is founded with the mission to advance understanding of the molecular mechanisms of urinary protein loss and associated kidney diseases.
Program in Nutritional Metabolism
The Mass General Program in Nutritional Metabolism was formed in 2002 under the Direction of Steven Grinspoon, MD, an expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.
Psychiatric Neuroscience
The Psychiatric Neuroscience Division is comprised of several programs, encompassing research, training and clinical services.
Psychiatric Neuroscience: Epidemiology Research
Epidemiology provides a public health perspective on mental health and mental illness in that it is concerned with psychiatric disorders in the general population.
Psychiatric Neuroscience: Gerontology Research
The Geriatric Neurobehavioral Clinic at Massachusetts General Hospital offers a multidisciplinary and individualized approach to the diagnosis of persons with memory disorders.
Psychiatric Neuroscience: Neurochemistry
Successfully studying novel chemotherapeutic agents for clinical trials in Alzheimer patients.
Psychiatric Neuroscience: Neurotherapeutics
The MGH Psychiatric Neurotherapeutics Program encompasses the clinical, research and training activities related to device-based treatments for psychiatric disorders.
Psychiatric Neuroscience: Post Traumatic Stress Disorder and Psychophysiology Lab
The laboratory's mission is to perform state-of-the-art psychobiological research into the assessment, pathophysiology, prevention, and treatment of post-traumatic stress disorder.
Psychiatric Neuroscience: Psychiatric and Neurodevelopment Genetics Unit
In addition to gaining more information about psychiatric disorders, we are interested in understanding how genes are passed on from generation to generation and also very interested in finding susceptibility genes.
Psychiatric Neuroscience: Psychiatric Neuroimaging
The MGH Psychiatric Neuroimaging Research Program focuses on a broad scope of research topics uniting many collaborators across neuroscience disciplines, and utilizing a full complement of neuroimaging technologies.
Psychotherapy Research Program
The Psychotherapy Research Program at Massachusetts General Hospital was formed in 1999 to study the process and outcome of psychotherapy empirically.
Radiation Oncology Biostatistics & Biomathematics
The Division of Biostatistics & Biomathematics supports research-oriented databases and data management needs for Radiation Oncology.
Rajagopal Lab
Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system since there is an abundance of respiratory diseases of unknown cause without cures.
Raje Lab
Research topics include: multiple myeloma; tumor microenvironment; bone disease and myeloma; novel therapies for multiple myeloma
Ramaswamy Lab
Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational Biology.
Ramaswamy Lab
Metastatic cancers are generally incurable due to drug resistance that is thought to be mediated through poorly defined genetic networks that normally regulate stem cell behavior. We are using genomic approaches to systematically define and probe these networks. We use genome-scale profiling to generate global views of metastatic cancer at the molecular level; methods in cell biology and bioengineering to experimentally model cancer progression in vitro and in vivo; high-throughput genetic, chemical, and imaging tools to functionally interrogate these models; and computational biology and statistics for the in silico integration and analysis of this complex data stream. Our major aim is to guide the development and clinical use of next-generation cancer drugs and diagnostics.
Raymond Chung's Laboratory
Our project will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been nonresponders or ineligible to receive current treatments.
Reinecker Lab
Our laboratory is interested in the discovery of genes and the molecular mechanisms of their function in the regulation of the intestinal epithelial cell barrier function, intestinal microbial recognition and mucosal host defense mechanisms.
Reproductive Endocrine
Select a topic from this list to view a detailed description of the study:
Reproductive Endocrine Unit All Research
The Reproductive Endocrine Unit in the Endocrine Division at Massachusetts General Hospital hosts a broad-based clinical and basic scientific research program into the scientific basis of reproductive disorders in the human.
Robert Wood Johnson Foundation
The Nursing Ambulatory to Hospital Transitions Program (NAHT) - 2 year award.
Rocco Lab
Research topics include: P63 mediators as targets in head and neck cancer
Sarcoma Molecular Biology Laboratory
The Orthopaedic Oncology Laboratory continues to seek factors that may serve as predictors of metastasis in malignant bone and soft tissue tumors both by molecular and biochemical studies and by flow cytometric analyses of DNA ploidy and cell cycle parameters.
Sarcomas & Soft Tissue Tumors Clinical Research
The Center for Sarcoma and Connective Tissue Oncology offers a truly multidisciplinary approach to care, including research and clinical trials conducted as part of one of the largest hospital-based programs in the nation.
Scadden Lab
The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.
Schizophrenia Program
The Schizophrenia Program offers a wide range of clinical services in addition to offering a unique international consultation service to patients and their families.
Schmidt Lab
Research topics include: Cyclin D1
Settleman Lab
Research topics include: targeted therapies; signaling in cancer; PI3K signaling pathway; EGFR inhibitors in cancer; sensitivity and resistance to targeted therapies
Sgroi Lab
Research topics include: breast cancer
Sharma Lab
Research topics include: Targeted Anti-cancer Therapeutics on Epidermal Growth Factor Receptor (EGFR)
Shioda Lab
Research topics include: signaling of mammary epithelial cells
Skeletal Biology Research Center
The Skeletal Biology Research Center of the Department of Oral and Maxillofacial Surgery does pioneering work to apply advances is biomedical engineering, biomechanics, tissue engineering, and computer-aided surgical planning to the art of reconstruction or congenital and acquired facial deformities.
Stoeckle Center Research
Current Stoeckle Center research initiatives focus on evaluating educational programs, tools and interventions to identify best clinical practices and the most effective ways to involve patients and families in shared decision-making.
Stroke Service Research
Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.
Supko Lab
Research topics include: pharmacokinetic studies of new anticancer agents
Sweetser Lab
Research topics include: leukemia; AML; Groucho/TLE; mouse models; stem cells
Tanabe Lab
Research topics include: hepatobiliary cancer; Epidermal Growth Factor and hepatocellular carcinoma
Thayer Lab
The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.
The Alan and Lorraine Bressler Clinical and Research Program for Autism Spectrum Disorders
To improve the clinical care of children and adults with autism spectrum disorders, to advance the education of patients, families and service providers about these conditions, and to expand the scientific understanding of these disorders.
Thoracic Cancers Clinical Research
Lung cancer is the leading cause of cancer-related mortality in the United States. Despite great advances in the understanding of lung cancer biology, only 15% of patients are alive five years after diagnosis. The research program of the Center for Thoracic Cancers is a multifaceted effort designed to understand thoracic cancer biology, discover novel agents and improve treatment.
Tissue Engineering & Organ Fabrication Lab
The Tissue Engineering & Organ Fabrication Lab is designing and building new, living tissues and organs for patients. We have worked in the field of Tissue Engineering since 1985. We have designed and tested 27 tissues of the body including vital organs needed for transplantation.
TRANSCEND Research Laboratory, Martha Herbert, MD, PhD
TRANSCEND. Treatment Research and NeuroSCience Evaluation of Neurodevelopmental Disorders.
Transplant Biology Research Center
The mission of the TBRC is to understand the basic immunologic mechanisms through which specific tolerance can be induced for organ and bone marrow transplant recipients, and to find creative new means of dealing with the shortage of available organs.
Transplantation Biology Research Center (TBRC)
The Large Animal Transplantation Laboratory utilizes partially inbred miniature swine as a large animal pre-clinical model. Major collaborative studies within the TBRC and between the TBRC and the Transplant Unit of the Surgery Department are carried out.
Trauma Research Laboratory
Research at the Trauma Research Laboratory targets critical aspects of early trauma care, focusing on clearly defined high-impact goals.
Tsao Lab
The overall goal of my research effort is to better understand the genetic basis of melanoma formation and the clinical realization of these molecular events.
Type 2 Diabetes Laboratory Research
The Diabetes Lab focuses on studies relating to insulin resistance in Diabetic patients.
United States Critical Illness and Injury Trials Group (USCIITG)
The USCIIT Group aims to establish a critical care research consortium for the United States.
Vacanti Lab
Our tissue engineering research lies at the interface between basic and translation work where we focus on regenerating or replacing diseased organs and tissues. Combining the disciplines of medicine, molecular and developmental biology, material science, and biotechnology, we have applied tissue engineering principles to design and engineer replacement tissues.
Vascular Biology Research Laboratory
The Vascular Surgery Research Laboratory is involved in experimental strategies geared towards understanding the pathophysiology of intimal hyperplasia and ischemia reperfusion injury. We are also involved in the development of novel clinically relevant experimental therapies to treat and/or prevent both of these complex problems.
Vasudevan Lab
Research topics include: non-coding RNAs, microRNAs, AU-rich elements, Translation, Cytokines, VEGF, oocytes, cell cycle, quiescence
Warshaw Lab
The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.
Whetstine Lab
Research topics include: histone demethylase; chromatin; C. elegans; transcription; epigenetics; JMJC; HDAC
Willers Lab
Research topics include: lung cancer; radiation; EGFR; molecular targeting; DNA repair
Women's Mental Health
Please see our website for Women’s Mental Health, a perinatal and reproductive psychiatry information center, at www.womensmentalhealth.org.
Xavier Lab
Our research focuses on PDZ proteins in cell signaling and on genomic computational approaches in immunity.
Xu Lab
Research topics include: tumor angiogenesis and metastasis; tumor microenvironment
Yajnik Lab
My principal interest is to understand the molecular basis of cancer progression.
Zou Lab
Research topics include: DNA damage response; DNA damage checkpoint; checkpoint signaling; checkpoint activation; genomic instability
Biostatistics Unit
The Biostatistics Center maintains a combined research and collaborative program that focuses on the development and application of quantitative methods relevant to cancer.
Cancer Pharmacology Core
The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.
Cardiovascular Imaging Core Lab
The Cardiovascular Imaging Core Lab at Massachusetts General Hospital is an independent facility dedicated to providing the highest quality services to the cardiovascular imaging community.
CBRC Cores
Overview of CBRC Cores. Please follow the link below for the main MGH Cores page
Center for Cancer Risk Assessment
The Center for Cancer Risk Assessment (CCRA) is devoted to the integration of molecular genetics and the clinical study of cancer predisposition. The Center has both laboratory and clinical components.
Center for Molecular Therapeutics
The Center for Molecular Therapeutics is actively investigating better ways to match individual cancer patients with particular targeted drug therapies in order to maximize the likelihood of a clinical response.
Center for Outcomes Research
Our research focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.
hESC Core Facility
The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.
HSCI-CRM Flow Cytometry Core Facility
Offers custom-built instrumentation for cell sorting and data analysis.
Institute for Healthcare Policy
The Institute for Health Policy (IHP) is dedicated to conducting world-class research on the leading health issues.
Light Microscopy and Image Analysis Core
Includes state-of-the art Nikon upright (80i) and inverted (TE2000-U) microscopes.
Mental Health & The Media
The mission of the Center for Mental Health and Media is to save lives, comfort and educate families, and to change the public's outdated and inaccurate perceptions of the nature, causes and treatment of mental illness.
MGH Tissue Repository
The goal of the Massachusetts General Hospital Tissue Repository is to collect human tumor surgical specimens for distribution to researchers in the Massachusetts General Hospitals scientific community, and to the broader biomedical science community as well. Tumor specimens are now available for distribution to researchers.
Molecular Profiling Laboratory
The Molecular Profiling Laboratory (MPL) is one of the Cancer Center research centers that provide technological support to Cancer Center investigators.
Mood & Anxiety Disorders Institute (MADI)
The Center translates the latest research advances into practical information to help people work with their doctors toward the most accurate diagnosis and best possible treatment results.
Neurogenetics DNA Diagnostic Laboratory
The Neurogenetics DNA Diagnostic Laboratory conducts standard-setting molecular DNA diagnostic testing for over 25 rare neurodegenerative disorders.
Pallative Care
The Palliative Care Service, in conjunction with the Harvard Medical School Center for Palliative Care, continues to focus research on innovative projects to promote education in end-of life care for health care professionals.
Phase I Clinical Trials Program
Basic research is necessary to achieve an understanding of the normal and pathological state, but cannot, by itself, put new knowledge to useful applications. The bridge to application is created by the development of diagnostic tests, new drugs or treatment approaches that allow an intervention in patients.
Psychiatric Oncology
As a collaboration between the Department of Psychiatry, consistently rated the best program in the US, and the Cancer Center, we are able to complement the research on cancer treatments by focusing on the psychological and behavioral aspects of cancer.
Specialized Histopathology Services
Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research.
The Analytical and Quantitative Cytology Core Facility
The Analytical and Quantitative Cytology Core Facility offers services and equipment to perform most flow cytometric assays.
Tobacco Research and Treatment Center
The Tobacco Research and Treatment Center's clinical research aims to identify effective tobacco treatment strategies and adapt them for the smokers who come to the health care setting.
Translational Research Laboratory
The Translational Research Laboratory is a dedicated laboratory aimed at rapid and targeted analysis of tumor specimens, in collaboration with treating physicians.
Tumor Imaging Metrics
The mission of the Tumor Imaging Metrics Core (TIMC) is to provide standardized, consistent, longitudinal radiological measurements to evaluate therapeutic response for DF/HCC clinical trials.
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