Guillermo J. Tearney, M.D., Ph.D.

Associate Professor

Wellman Center for Photomedicine

Massachusetts General Hospital

Research Interests

My current research interests are primarily focused on the development and validation of non-invasive, high-resolution optical methods for disease diagnosis. As a pathologist, I have a particular emphasis on conducting microscopy in living patients. Projects span early invention to large multidisciplinary clinical trials. A list of research topics is provided below:

• Optical coherence tomography (OCT): cardiovascular and gastrointestinal applications
• Optical frequency domain imaging (OFDI): high-speed OCT
• Spectrally encoded confocal microscopy (SECM): confocal microscopy through a small-diameter probe or endoscope
• Ultraminiature 3D endoscopy
• Intracoronary Raman spectroscopy
• Fluorescence lifetime and excitation-emission spectroscopy
• Smart needle: optical guidance of biopsy
• Laser speckle imaging: determine biomechanical properties of tissue
• Wide-field microscopy: full-slide scanning
• Self-interference fluorescence microscopy
• Infrared microscopy