Publications by Tayyaba Hasan, Ph.D.

2000

Del Governatore M, Hamblin MR, Piccinini EE, Ugolini G, Hasan T. Targeted photodestruction of human colon cancer cells using charged 17.1a chlorine6 immunoconjugates. Br J Cancer 2000; 82:56-64.

Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KL, Tanabe KK, Hasan T. Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorine6 immunoconjugate. Cancer Res 2000; 60:4200-4205.

Hamblin MR, Del Governatore M, Rizvi I, Hasan T. Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer. Br J Cancer 2000; 83:1544-1551.

Lein M, Jung K, Le D, Hasan T, Ortel B, Bochert D, Giessing M, Schnorr D, Loening S. Synthetic inhibitor of matrix metalloproteinases (Batimastat) reduce prostate cancer growth in a orthotopic rat model. Prostate 2000; 43(2):77-82.

Lein M, Ortel B, Koenig F, Misdraji J, McDougal WS, Jung K, Loening SA, Hasan T. Laser-induced hyperthermia in rat prostate cancer: role of site of tumor implantation. J Urol 2000; 56:167-172.

Molpus KL, Hamblin MR, Rizvi I, Hasan T. Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecol Oncol 2000; 76:397-404.

Schmidt U, Hasan T. Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degradation. Surv Ophthalmol 2000; 45:195-214.

2001

Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV, Hasan T. Pegylation of a chlorine6 polymer conjugate increases tumor targeting of photosensitizer. Cancer Res 2001; 61:7155-7162.

Heitner T, Moor A, Garrison JL, Marks C, Hasan T, Marks JD. Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library. J Immunol Methods 2001; 248:17-30.

Pogue BW, Ortel B, Chen N, Redmond RW, Hasan T. A photobiological and photophysical-based study of phototoxicity of two chlorins. Cancer Res 2001; 61:717-724.

Soukos NS, Hamblin MR, Keel S, Fabian RL, Deutsch TF, Hasan T. Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer In-vivo . Cancer Res 2001; 61:4490-4496.

Sullivan LG, Hasan T, Wright M, Mankin HJ, Towle CA. Photodynamic treatment has chondroprotective effects on articular cartilage. J Orthop Res 2001; 221:1-8.

2002

Duska LR, Wimberly J, Deutsch TF, Ortel B, Haas J, Houck K, Hasan T. Detection of female lower genital tract dysplasia using orally administered 5-Aminolevulinic acid (ALA) induced protoporphyrin IX: A Preliminary Study. J Gyn Onco 2002; 85:125-128.

Haimovici R, Hasan T. Localization of Rose Bengal, CASPc, and Chlorin e6 in the rabbit eye. Retina 2002; 22:65-74.

Hamblin MR, O'Donnell DA, Murthy N, Contag CH, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by In-vivo bioluminescence imaging. Photochem Photobiol 2002; 75(1):51-57.

Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, Hasan T. Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J Antimicrob Chemoth 2002; 49:941-951.

Ortel B, Sharlin D, O'Donnell D, Sinha AK, Maytin EV, Hasan T. Differentiation enhances aminolevulinic acid-dependent photodynamic treatment of LNCAP prostate cancer cells. Br J Cancer 2002; 87:1321-1327.

2003

Chen B, Pogue BW, Goodwin IA, O'Hara JA, Wilmot CM, Hutchins JE, Hoopes PJ, Hasan T. Blood flow dynamics following photodynamic therapy with verteporfin in the RIF-1 tumor. Radiat Res 2003; 160(4):452-459.

Hamblin MR, Miller JL, Rizvi I, Loew HG, Hasan T. Pegylation of charged polymer-photosensitizer conjugates: effects on photodynamic efficacy. Br J Cancer 2003; 89:937-943.

Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T. Optical monitoring and treatment of potentially lethal wound infections In-vivo . J Infect Dis 2003; 187:1717-1725.

Jung K, Krell HW, Ortel B, Hasan T, Romer A, Schnorr D, Loening SA, Lein M. Plasma matrix metalloproteinase 9 as biomarker of prostate cancer progression in Dunning (Copenhagen) rats. Prostate 2003; 54(3):206-211.

Pogue B, Hasan, T. Targeting in photodynamic therapy and photo-imaging. OPN 2003; 14(8):36-43.

Pogue BW, O'Hara JA, Demidenko E, Wilmot CM, Goodwin IA, Chen B, Swartz HM, Hasan T. Photodynamic therapy with verteporfin in the radiation-induced fibrosarcoma-1 tumor causes enhanced radiation sensitivity. Cancer Res 2003; 63(5):1025-1033.

Savellano M, Hasan T. Targeting cells that overexpress the epidermal growth factor receptor with PEGylated BPD verteporfin photosensitizer immunoconjugates. Photobiochem Photobiol 2003; 77(4): 431-439.

2004

Gad F, Zahra T, Hasan T, Hamblin MR. Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteria. Antimicrob Agents Chemother 2004;48(6):2173-8.

Gad F, Zahra T, Francis K, Hasan T, Hamblin MR. Targeted photodynamic therapy of established soft-tissue infections in mice. Photochem Photobiol Sci 2004;3(5):451-458.

Georgakoudi I, Solban N, Novak J, Rice WL, Wei X, Hasan T, Lin CP. In-vivo flow cytometry: a new method for enumerating circulating cancer cells. Cancer Res 2004;64:5044-7.

Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004;3(5):436-50.

Zhou X, Pogue, BW, Chen B, Hasan, T. Analysis of effective molecular diffusion rates for verteporfin in subcutaneous versus orthotopic Dunning prostate tumors. Photochem Photobiol 2004;79(4): 323-31.

2005

Chen B, Pogue BW, Hoopes PJ, Hasan T. Combining vascular and cellular targeting regimens enhances the efficacy of photodynamic therapy. Int J Radiat Oncol 2005;61(4):1216-26.

Chen B, Pogue BW, Zhou X, O'Hara JA, Solban N, Demidenko E, Hoopes PJ, Hasan T. Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model. Cancer Res 2005;11(2 Pt 1):720-7.

Chen B, Pogue BW, Hasan T. Liposomal delivery of photosensitizing agents. [Review] Expert Opin Drug Deliv 2005;2(3):477-87.

Chen TC, Cense B, Pierce MC, Nassif N, Park BH, Yun SH, White BR, Bouma BE, Tearney GJ, de Boer JF. Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging. Arch Ophthalmol. 2005;123(12):1715-20.

del Carmen MG, Rizvi I, Chang Y, Moor AC, Oliva E, Sherwood M, Pogue B, Hasan T. Synergism of epidermal growth factor receptor-targeted immunotherapy with photodynamic treatment of ovarian cancer in vivo. J Natl Cancer Inst 2005;97(20):1516-24.

Lambrechts SA, Demidova TN, Aalders MC, Hasan T, Hamblin MR. Phtodynamic therapy for Staphylococcus aureus infected burn wounds in mice. Photochem Photobiol 2005;4:503-9.

O'Riordan K, Akilov OE, Hasan T. The potential for photodynamic therapy in the treatment of localized infections. [Review] PPT 2005;2:247-62.

Savellano MD, Hasan T. Photochemical targeting of epidermal growth factor receptor: a mechanistic study. Clin Cancer Res 2005;11(4):1658-68.

Solban N, Ortel B, Pogue B, Hasan T. Targeted optical imaging and photodynamic therapy. [Review] Ernst Schering Res Found Workshop. 2005;(49):229-58.

2006

Akilov OE, Kosaka S, O'Riordan K, Song X, Sherwood M, Flotte TJ, Foley JW, Hasan T. The role of photosensitizer molecular charge and structure on the efficacy of photodynamic therapy against Leishmania parasites. Chem Biol 2006;13(8):839-47.

Casas A, Perotti C, Ortel B, Di Venosa G, Saccoliti M, Batlle A, Hasan T. Tumor cell lines resistant to ALA-mediated Photodynamic Therapy and possible tools to target surviving cells. Int J Oncol 2006;29(2):397-405.

Chen B, Pogue BW, Hoopes PJ, Hasan T.  Vascular and cellular targeting for photodynamic therapy.  Eukaryotic Gene Expression 2006;16(4):279-305.

Chen B, Pogue BW, Luna JM, Hardman RL, Hoopes PJ, Hasan T. Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications. Clin Cancer Res 2006 Feb;12(3):917-23.

Gibbs SL, Chen B, O'hara JA, Hoopes PJ, Hasan T, Pogue BW. Protoporphyrin IX Level Correlates with Number of Mitochondria, but Increases in Production Correlate with Tumor Cell Size. Photochem Photobiol 2006;82:1334-41.

Kosaka S, Kawana S, Zouboulis CC, Hasan T, Ortel B. Targeting of sebocytes by aminolevulinic acid-dependent photosensitization. Photochem Photobiol 2006;82(2):453-7.

Kosharskyy B, Solban N, Chang SK, Rizvi I, Chang Y, Hasan T. A mechanism-based combination therapy reduces local tumor growth and metastasis in an orthotopic model of prostate cancer. Cancer Res 2006;66(22):10953-8.

O'Riordan K, Sharlin DS, Gross J, Chang S, Errabelli D, Akilov OE, Kosaka S, Nau GJ, Hasan T. Photoinactivation of Mycobacteria in vitro and in a new murine model of localized Mycobacterium bovis BCG-induced granulomatous infection. Antimicrob Agents Chemother 2006;50(5):1828-34.

Sato N, Moore B, Keevey S, Drazba J, Hasan T, Maytin EV. Vitamin D enhances ALA-mediated protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes. J Invest Dermatol 2006; [Epub ahead of print].

Sinha AK, Anand S, Ortel BJ, Chang Y, Mai Z, Hasan T, Maytin EV. Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells. Br J Cancer. 2006 Aug 21;95(4):485-95.

Solban N, Pal SK, Alok SK, Sung CK, Hasan T. Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer. Cancer Res 2006;66(11):5633-40.

Solban N, Rizvi I, Hasan T. Targeted photodynamic therapy. Laser Surg Med 2006;38(5):522-31.

Yelin D, Rizvi I, White WM, Motz JT, Hasan T, Bouma BE, Tearney GJ. Three-dimensional miniature endoscopy. Nature 2006;443:765.

Zhou X, Pogue BW, Chen B, Demidenko E, Joshi R, Hoopes J, Hasan T. Pretreatment photosensitizer dosimetry reduces variation in tumor response. Int J Radiat Oncol Biol Phys 2006;64(4):1211-20.

Zhou X, Chen B, Hoopes PJ, Hasan T, Pogue BW.  Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the dunning rat prostate tumor.  Photochem Photobiol 2006;82(5):1348-57.

2007

Akilov OE, Donovan MJ, Stepinac T, Carter CR, Whitcomb JP, Hasan T, McDowell MA. T helper type 1 cytokines and p38 MAPK play a critical role in pseudoepitheliomatous hyperplasia initiation during cutaneous leishmaniasis. Arch Dermatol Res 2007;299(7):315-25.

Akilov OE, Khachemoune A, Hasan T.  Clinical manifestations and classification of Old World cutaneous leishmaniasis. Int J Dermatol 2007;46:132-42.

Akilov OE, Kosaka S, O'riordan K, Hasan T. Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells. Exp Dermatol 2007;16(8):651-60.

Akilov OE, Kosaka S, O'Riordan K, Hasan T. Photodynamic therapy for cutaneous leishmaniasis: The effectiveness of topical phenothiaziniums in parasite eradication and Th1 immune response stimulation. Photoch Photobio Sci 2007; 6(10):1067-75.

Kosaka S, Akilov OE, O'riordan K, Hasan T. A mechanistic study of delta-aminolevulinic acid-based photodynamic therapy for cutaneous Leishmaniasis. J Invest Dermatol 2007;127(6):1546-9.

O’Riordan K, Akilov OE, Chang SK, Foley JW, Hasan T. Real-time fluorescence monitoring of phenothiazinium photosensitizers and their anti-mycobacterial photodynamic activity against Mycobacterium bovis BCG in in vitro and in vivo models of localized infection. Photoch Photobio Sci 2007;6(10):1117-23

Sato N, Moore BW, Keevey S, Drazba JA, Hasan T, Maytin EV. Vitamin D enhances ALA-induced protoporphyrin IX production and photodynamic cell death in 3-D organotypic cultures of keratinocytes. J Invest Dermatol 2007;127(4):925-34.

Sheng C, Hoopes PJ, Hasan T, Pogue BW. Photobleaching-based dosimetry predicts deposited dose in ALA-PpIX PDT of rodent esophagus. Photochem Photobiol 2007;83:738-48.

Styer AK, Sullivan BT, Puder M, Arsenault D, Petrozza JC, Serikawa T, Chang S, Hasan T, Gonzalez RR, Rueda BR.  Ablation of leptin signaling disrupts the establishment, development and maintenance of endometriosis-like lesions in a murine model.  Endocrinology 2007: Oct 25; [Epub ahead of print] PMID: 17962343

Verma S, Watt GM, Mai Z, Hasan T. Strategies for enhanced photodynamic therapy effects. Photochem Photobiol 2007;83(5):996-1005. [Review]

Zhou X, Chen B, Hoopes PJ, Hasan T, Pogue BW.  Peptide-induced inflammatory increase in vascular permeability improves photosensitizer delivery and intersubject photodynamic treatment efficacy.  Radiat Res 2007;168(3):299-307.

2008

Styer AK, Sullivan BT, Puder M, Arsenault D, Petrozza JC, Serikawa T, Chang S, Hasan T, Gonzalez RR, Rueda BR.   Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model.  Endocrinology. 2008;149(2):506-14.

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